Understanding Anxiety and Mood Swings in Perimenopause: the Progesterone Connection.

Navigating the menopausal transition can feel like an emotional rollercoaster. For many women, heightened anxiety, irritability, and mood swings emerge unexpectedly in their 40s. These shifts aren’t merely stress-related; they often stem from hormonal changes, particularly fluctuations in progesterone levels.

1.The Hormonal Rollercoaster: Oestrogen and Progesterone

During perimenopause, the period leading up to menopause, women experience significant hormonal fluctuations. Estrogen and progesterone levels can become erratic, leading to various physical and emotional symptoms. Progesterone, in particular, plays a crucial role in regulating mood. Its calming effects help maintain emotional stability. However, as progesterone levels decline, many women report increased feelings of anxiety and irritability

So, what exactly are Oestrogen and Progesterone, and what do they do?

Oestrogen and progesterone are primary female sex hormones produced mainly by the ovaries, though small amounts are also produced by the adrenal glands and fat tissue. These hormones play pivotal roles in regulating the menstrual cycle, supporting reproductive health, and influencing various bodily functions.

Oestrogen is responsible for:

  • Regulating the menstrual cycle.

     

  • Supporting the development of female secondary sexual characteristics.

     

  • Maintaining bone density.

     

  • Contributing to skin elasticity and vaginal health.

Oestrogen Fluctuations: Estrogen levels may fluctuate widely, causing symptoms such as hot flashes, night sweats, mood swings, and vaginal dryness.

Progesterone is crucial for:

  • Preparing the uterus for pregnancy.

     

  • Regulating the menstrual cycle.

     

  • Supporting early stages of pregnancy.

     

  • Promoting relaxation and sleep.

Progesterone Decline: Progesterone levels also decrease, affecting the uterine lining and contributing to changes in menstrual flow.

Progesterone has a natural sedative effect on the brain, promoting relaxation and calmness. As levels of this hormone decrease, many women experience heightened stress and emotional instability. Combined with the decline in estrogen, which also affects neurotransmitter activity, these hormonal changes can make women more vulnerable to emotional fluctuations.

3. Perimenopausal Rage: Understanding the Science Behind the Symptoms

Perimenopausal rage is real. It’s characterised by sudden, intense feelings of anger that may seem disproportionate to a situation. These emotional outbursts can wreak havoc in your relationships, with loved ones walking on eggshells or left feeling confused as your usual capacity to cope or navigate complex challenges fluctuates, and tolerance to stress decreases.

This can be overwhelming and may lead to feelings of guilt or confusion. It’s hard enough battling the feelings, and it makes matters worse when your best laid intentions end up in a rage outburst and you have to pick up the pieces from your outbursts. The underlying cause is largely hormonal fluctuations in oestrogen and progesterone levels, which can significantly impact mood regulation. You’re not being overly sensitive – you’re reacting to intense internal changes at a hormonal level. It’s important to educate your partner, family and friends about what you’re going through, so they can have a little compassion for the ups and downs, and not take them so personally.

Of course, its also important to get support and notice when things are escalating to avoid big blow ups that are unnecessary and cause conflict that’s draining and time-consuming to resolve.

4. Symptoms to Look Out For

It’s common for women to feel on edge, teary, or irritable without a clear trigger during perimenopause. These emotional shifts are not just psychological; they are biologically driven by unstable hormone levels. The decline in progesterone can lead to heightened rage and anxiety, while the drop in estrogen can affect neurotransmitters in the brain, further contributing to mood swings.

5. Get Support

While hormonal changes are a natural part of aging, there are strategies to manage anxiety and mood swings during perimenopause:

  • Consult a Healthcare Provider: Discuss symptoms with your doctor, nutritionist, or mental health professional to explore treatment options to support your physical and mental health.
  • Lifestyle Modifications: Consider regular physical activity, a balanced diet, and adequate sleep to help stabilise mood.
  • Mindfulness and Stress Management: Practices like meditation, yoga, and deep-breathing exercises can reduce stress and improve emotional well-being.
  • Reach Out: Connecting with others experiencing similar symptoms can provide comfort and understanding.

     

Experiencing anxiety, perimenopausal rage and mood swings during perimenopause is common and often linked to hormonal changes, particularly fluctuations in progesterone. Understanding the underlying causes can empower women to seek appropriate support and treatment, leading to improved emotional health during this transitional phase.

If you want help navigating your perimenopausal symptoms, my Sage Coaching program is scientifically designed to support women like you with a holistic, evidence-based program tailored to your body and lifestyle.


Visit www.cassandrairvin.com.au to learn more about Sage Coaching today.

Cass

References

American College of Obstetricians and Gynecologists. (2023, August 30). Mood changes during perimenopause are real. Here’s what to know. https://www.acog.org/womens-health/experts-and-stories/the-latest/mood-changes-during-perimenopause-are-real-heres-what-to-know

Cleveland Clinic. (2023, October 19). Perimenopause: Symptoms & causes. https://www.mayoclinic.org/diseases-conditions/perimenopause/symptoms-causes/syc-20354666

Feminine Health. (2025, May 15). What are mood swings during perimenopause? Here’s what to know. https://femininehealth.org/menopause/mood-swings-perimenopause/

Harvard Health Publishing. (2021, October 18). Perimenopause: A rocky road to menopause. https://www.health.harvard.edu/womens-health/perimenopause-rocky-road-to-menopause

Hopkins Medicine. (2023, November 10). Perimenopause and anxiety. https://www.hopkinsmedicine.org/health/wellness-and-prevention/perimenopause-and-anxiety

Mayo Clinic. (2023, October 19). Perimenopause: Symptoms & causes. https://www.mayoclinic.org/diseases-conditions/perimenopause/symptoms-causes/syc-20354666

Modern Menopause. (2025, March 22). Mood changes during perimenopause: How to find emotional balance. https://content.modernmenopause.ca/mood-changes-during-perimenopause/

Verywell Mind. (2020, October 8). Menopause and depression: What’s the connection?. https://www.verywellmind.com/the-connection-between-menopause-and-depression-4767577